NFL Betting: Top 10 Games to Watch this NFL Season

We preview the most-anticipated games of the upcoming season!

Jennifer SparrowJennifer Sparrow
June 27th, 2022
NFL betting
Steve Jacobson /

Bettors will be happy to learn that the NFL has announced its schedule for the regular season and there are some matchups that have everyone excited! These matchups are between some of the best teams in the league, some longtime rivals, and former players returning to play their old franchises. Here at, we have previewed the most-anticipated games of the regular season, giving you all the background information you need to place your wagers.

Week 1: Bills at Rams

The preseason betting favorite Buffalo Bills will face the reigning Super Bowl champions in the Los Angeles Rams week one. This will be a true test of who could take the No. 1 spot in the power rankings come the end of the first week of the NFL season. Both of these teams have high-powered offenses and elite defenses. It will also be the first chance to watch Josh Allen who is one of the most electrifying players in the entire league and at the quarterback position. This game will kickoff the season on Thursday night of week one on NBC. Look for a hard fought and a lot of offense to begin the 2022 NFL season.

Week 3: Packers at Buccaneers

There is likely no debate on who the greatest of all-time in the NFL is. By this point Tom Brady should have that title as he has pretty much every passing record, seven Super Bowl rings, and three MVPs. There is a debate around who the second-best player of all-time is though, and Aaron Rodgers is right up there in that conversation. Having possibly the best player in NFL history facing off against the second-best player ever at this point in their careers will always be one of the games that fans will look the most forward to. Both of these teams also are Super Bowl contenders this year and should be two of the top teams in the NFC who could see each other again down the line in the playoffs.

Week 15: ​​Patriots at Raiders

Fans who are into the storyline of Bill Belichick facing his former assistant coaches who grew and learned a ton and went on to have successful head coaching careers of their own should be intrigued by this matchup. Josh McDaniels spent eight years with the Patriots from 2001 to 2008 before he got his first head coaching opportunity. Then he returned to the team from 2012 up until this season. Now he is the head coach for the Raiders and will take on his former team and head coach of the Patriots. The Raiders and Patriots also have history after the infamous Brady tuck rule that prevented the Raiders from advancing to the Super Bowl. These two teams should be two of the best in the AFC and will put on a show in week 15.

Week 1: Broncos at Seahawks

The Seattle Seahawks fans won't have to wait long to see their former franchise quarterback playing back on their home field in Seattle. Literally the next regular season game that Russell Wilson will play after his last with the Seahawks will be against his old team and back in Seattle. This will likely be an emotional game that Wilson will have to push through. The Broncos are seen as Super Bowl contenders in their first season with Wilson as their quarterback, but the Seahawks are being predicted by many to struggle yet again in the 2022 season. This will also be a potential revenge game for Drew Lock who was drafted in the second round by the Denver Broncos in 2019 and played three seasons where he started at least three games in each year and also started 13 games in 2020.

Week 4: Chiefs at Buccaneers

Two of the best offenses in the past two seasons will go head-to-head in week four when the Chiefs play in Tampa Bay against the Buccaneers on Sunday night football on NBC. This game will be between two of the best quarterbacks in the NFL in Tom Brady and Patrick Mahomes. Both of these quarterbacks should be MVP candidates heading into the year and this game could prove pivotal for that race. This game should also be a shootout with these two offenses. It will also be a Super Bowl rematch from the 2021 Super Bowl where the Buccaneers beat the Chiefs in a blowout to kill the dreams of winning back-to-back Super Bowls for the Chiefs. It will be the first time these teams have played against each other since that Super Bowl game where the Bucs won 31-9.

Week 17: Rams at Chargers

In the second to last week of the NFL regular season, the Rams will play the Chargers in a home game for the Chargers in the battle of Los Angeles. These two teams are expected to be good, and this game could possibly have some seeding implications for the playoffs on the line in this contest. It is more about the battle of Los Angeles though as the Rams won the Super Bowl last year and also won the hearts of many of the LA fans. The Chargers will look to win back some fans by beating them in week 17 with their new retooled team that is expected to make a run of their own at the Super Bowl this upcoming season. This should be an entertaining game of Sunday night football that the fans will be highly anticipating.

Week 7: Saints at Cardinals

The Saints playing in Arizona against the Cardinals might not sound like a highly anticipated matchup that the fans will be waiting for, but come week seven everyone will be tuning in for this one. This game will mark the return of Deandre Hopkins to the Cardinals' lineup after serving his six-game suspension to start the season. Another possible return could be from Alvin Kamara for the Saints after he is expected to get a six-game suspension as well. Yet another storyline is Tyrann Mathieu's return to Arizona where he played the first five years of his career. The Cardinals were one of the best teams in the NFL for the first half of the season last year before they eventually fell apart. They will look to bounce back this year, and if they are in a good spot by week seven, they should be even better in this one with Hopkins returning. The Saints are a team that disappointed last season, but they were without their starting quarterback, Jameis Winston, after he tore his ACL and have retooled this lineup getting Mathieu and Michael Thomas returning as well.

Week 10: Browns at Dolphins

Deshaun Watson is expected to get a lengthy suspension that has yet to be announced. It is expected though that he should be back for week 10. Whether this is his first game back or one of his first games back, it will likely be one of the most anticipated games of the week. If the Browns have a good record or not come week 10 it won't matter as the allure of seeing Watson finally play an NFL game again and for a new franchise will be appealing enough for any NFL fan. It will also be equally as interesting to see where the Miami Dolphins are at this point in the season as they are expected to be at least one of the most entertaining teams in the league with Tyreek Hill, Roheem Mostert, and Cedrick Wilson all now on their offense.

Week 4: Rams at 49ers

The Rams and 49ers have one of the best division rivalries in the NFL. These two teams seem to always have one of the best games of the week any time they play. Before losing to the Rams in the NFC Conference Title game last year, the 49ers had beaten the Rams six times in a row. The 49ers should feel like they got slighted by the Rams as they lost their chance to play for a Super Bowl last season. This matchup in week four could set an early tone for who is the best this year in the NFC West. It is expected at this point that the Rams are the favorite in the division, but the 49ers will be looking to prove people wrong. San Francisco will look to show the entire NFL that they are for real this year in their first big game of the season that could prove that.

Week 5: Bengals at Ravens

Joe “Cool” Burrow will get his chance to show the league that the Bengals' run to the Super Bowl last year was not a fluke as Cincinnati takes on Baltimore on the road in week five. Many sportsbooks have the Ravens as the favorite in the AFC North over the Bengals this upcoming year even after the Bengals made it all the way to the Super Bowl just last season. So far in his NFL career Lamar Jackson has been good, but he really hasn't won anything yet. Winning this division and making enough noise in the playoffs to beat the Chiefs or Bills finally is really what he should be aiming for this year to take the Ravens to a Super Bowl. Look for this to be one of the games of the week as two division rivals go at it.

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